A Perspective on Natural and Nature-Inspired Small Molecules Targeting Phosphodiesterase 9 (PDE9): Chances and Challenges against Neurodegeneration

• Main Authors: Giovanni Ribaudo (Author), Maurizio Memo (Author), Alessandra Gianoncelli (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2021-01-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

As life expectancy increases, dementia affects a growing number of people worldwide. Besides current treatments, phosphodiesterase 9 (PDE9) represents an alternative target for developing innovative small molecules to contrast neurodegeneration. PDE inhibition promotes neurotransmitter release, amel...