Soluble guanylyl cyclase: A novel target for the treatment of vascular cognitive impairment?

• المؤلفون الرئيسيون: Ellis Nelissen (مؤلف), Melissa Schepers (مؤلف), Laura Ponsaerts (مؤلف), Sébastien Foulquier (مؤلف), Annelies Bronckaers (مؤلف), Tim Vanmierlo (مؤلف), Peter Sandner (مؤلف), Jos Prickaerts (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2023-11-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Vascular cognitive impairment (VCI) describes neurodegenerative disorders characterized by a vascular component. Pathologically, it involves decreased cerebral blood flow (CBF), white matter lesions, endothelial dysfunction, and blood-brain barrier (BBB) impairments. Molecularly, oxidative stress an...