Soluble guanylyl cyclase: A novel target for the treatment of vascular cognitive impairment?

• Main Authors: Ellis Nelissen (Author), Melissa Schepers (Author), Laura Ponsaerts (Author), Sébastien Foulquier (Author), Annelies Bronckaers (Author), Tim Vanmierlo (Author), Peter Sandner (Author), Jos Prickaerts (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vascular cognitive impairment (VCI) describes neurodegenerative disorders characterized by a vascular component. Pathologically, it involves decreased cerebral blood flow (CBF), white matter lesions, endothelial dysfunction, and blood-brain barrier (BBB) impairments. Molecularly, oxidative stress an...