Structure-Activity Relationship Studies of 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen-2-yl)-1,3,5-triazin-2-amine (FPMINT) Analogues as Inhibitors of Human Equilibrative Nucleoside Transporters

• Hoofdauteurs: Renkai Li (Auteur), Winston Wing-Shum Mak (Auteur), Jingjing Li (Auteur), Chengwen Zheng (Auteur), Polly Ho-Ting Shiu (Auteur), Sai-Wang Seto (Auteur), Simon Ming-Yuen Lee (Auteur), George Pak-Heng Leung (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Equilibrative nucleoside transporters (ENTs) play a vital role in nucleotide synthesis, regulation of adenosine function and chemotherapy. Current inhibitors of ENTs are mostly ENT1-selective. Our previous study has demonstrated that 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen...