Translocation of IGF-1R in endoplasmic reticulum enhances SERCA2 activity to trigger Ca2+ER perturbation in hepatocellular carcinoma

• Main Authors: Yanan Li (Author), Keqin Li (Author), Ting Pan (Author), Qiaobo Xie (Author), Yuyao Cheng (Author), Xinfeng Wu (Author), Rui Xu (Author), Xiaohui Liu (Author), Li Liu (Author), Jiangming Gao (Author), Wenmin Yuan (Author), Xianjun Qu (Author), Shuxiang Cui (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The well-known insulin-like growth factor 1 (IGF1)/IGF-1 receptor (IGF-1R) signaling pathway is overexpressed in many tumors, and is thus an attractive target for cancer treatment. However, results have often been disappointing due to crosstalk with other signals. Here, we report that IGF-1R signali...