Therapeutic targeting of mitochondrial ROS ameliorates murine model of volume overload cardiomyopathy

• Main Authors: Kenichi Okamura (Author), Yu Nakagama (Author), Norihiko Takeda (Author), Katsura Soma (Author), Tatsuyuki Sato (Author), Takayuki Isagawa (Author), Yasutoshi Kido (Author), Masaya Sakamoto (Author), Ichiro Manabe (Author), Yasutaka Hirata (Author), Issei Komuro (Author), Minoru Ono (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Concomitant heart failure is associated with poor clinical outcome in dialysis patients. The arteriovenous shunt, created as vascular access for hemodialysis, increases ventricular volume-overload, predisposing patients to developing cardiac dysfunction. The integral function of mitochondrial respir...