Impact of 11q Loss of Heterozygosity Status on the Response of High-Risk Neuroblastoma With MYCN Amplification to Neoadjuvant Chemotherapy

• Main Authors: Xian-Ying Lu (Author), Li-Jun Qu (Author), Xian-Lun Duan (Author), Wei Zuo (Author), Kai Sai (Author), Gang Rui (Author), Xian-Feng Gong (Author), Yi-bo Ding (Author), Qun Gao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PurposeThe aim of this study was to investigate whether 11q loss of heterozygosity (LOH) aberration would impact the response of the primary tumor to neoadjuvant chemotherapy or to the degree of surgical resection in neuroblastoma (NB) patients with MYCN amplification.MethodsThe clinical data of 42...