Clavulanic Acid Production by <i>Streptomyces clavuligerus</i>: Insights from Systems Biology, Strain Engineering, and Downstream Processing
Clavulanic acid (CA) is an irreversible β-lactamase enzyme inhibitor with a weak antibacterial activity produced by <i>Streptomyces clavuligerus</i> (<i>S. clavuligerus</i>). CA is typically co-formulated with broad-spectrum β‑lactam antibiotics such as amoxicillin, conferrin...
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