Inactivation of Ras and Changes of Mitochondrial Membrane Potential Contribute to Oridonin-Induced Autophagy in A431 Cells

• Egile Nagusiak: Dan Li (Egilea), Qiao Cui (Egilea), Shen-geng Chen (Egilea), Li-jun Wu (Egilea), Shin-ichi Tashiro (Egilea), Satoshi Onodera (Egilea), Takashi Ikejima (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2007-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

We have previously shown that oridonin isolated from Rabdosia rubescens augmented apoptosis while inhibiting autophagy within 24 h in HeLa cells. However, the mechanisms between apoptosis and autophagy induced by oridonin in A431 cells are largely unknown. Here, it was found that autophagic level is...