Application of lactobionic acid and nonionic surfactants as solubilizing agents for parenteral formulation of clarithromycin

• Main Authors: Mohammad-Hosein Zarrintan (Author), Hadi Valizadeh (Author), Saeed Ghanbarzadeh (Author), Parvin Zakeri-Milani (Author), Niaz Mousavian-Fathi (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2012-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: The purpose of this paper is to enhance the solubility of clarithromycin (CLR) using nonionic surfactants and some type of acids for preparation of the new formulations. Methods: Myrj 52 and chremophor (2.5 and 5% w/v) were used in two concentrations. To investigate solubility, the formulat...