Kidney protective effect of sitagliptin in 5-fluorouracil-challenged rats

• Autori principali: Ahmed Hassan Al-Ghamdi (Autore), Mervat Z. Mohamed (Autore), Rabei M. Elbadry (Autore), Amr A. Fouad (Autore)
• Natura: Libro
• Pubblicazione: Pensoft Publishers, 2024-02-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The possible protective effect of sitagliptin (SIT) against nephrotoxicity induced by a single dose 5-fluorouracil (5-FU) (150 mg/kg, i.p.) was investigated in rats. SIT treatment (5 and 10 mg/kg/day, p.o.) was given for 7 days, starting 5 days before 5-FU administration. Both SIT doses caused signi...