β-CA-specific inhibitor dithiocarbamate Fc14-584B: a novel antimycobacterial agent with potential to treat drug-resistant tuberculosis

• Main Authors: Ashok Aspatwar (Author), Milka Hammarén (Author), Sanni Koskinen (Author), Bruno Luukinen (Author), Harlan Barker (Author), Fabrizio Carta (Author), Claudiu T. Supuran (Author), Mataleena Parikka (Author), Seppo Parkkila (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhibition of novel biological pathways in Mycobacterium tuberculosis (Mtb) creates the potential for alternative approaches for treating drug-resistant tuberculosis. In vitro studies have shown that dithiocarbamate-derived β-carbonic anhydrase (β-CA) inhibitors Fc14-594 A and Fc14-584B effectively...