Targeting Liver <i>Xor</i> by GalNAc-siRNA Is an Effective Strategy for Hyperuricemia Therapy

• Main Authors: Huiyan Sun (Author), Xinxia Wang (Author), Yongqiang Li (Author), Yingzhi Shen (Author), Lin Zhang (Author), Yingjie Xu (Author), Junling Liu (Author), Xuemei Fan (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hyperuricemia, i.e., increased plasma uric acid concentration, is a common problem in clinical practice, leading to gout or nephrolithiasis, and is associated with other disorders, such as metabolic syndrome, cardiovascular disease, and chronic renal disease. Xanthine oxidoreductase (XOR) is a criti...