Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1β induced hypothermia and reflex anti-inflammatory responses

• Main Authors: Harold A. Silverman (Author), Aisling Tynan (Author), Tyler D. Hepler (Author), Eric H. Chang (Author), Manojkumar Gunasekaran (Author), Jian Hua Li (Author), Tomás S. Huerta (Author), Tea Tsaava (Author), Qing Chang (Author), Meghan E. Addorisio (Author), Adrian C. Chen (Author), Dane A. Thompson (Author), Valentin A. Pavlov (Author), Michael Brines (Author), Kevin J. Tracey (Author), Sangeeta S. Chavan (Author)
• Format: Book
• Published: BMC, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Inflammation, the physiological response to infection and injury, is coordinated by the immune and nervous systems. Interleukin-1β (IL-1β) and other cytokines produced during inflammatory responses activate sensory neurons (nociceptors) to mediate the onset of pain, sickness beha...