Mitochondrial dysfunction and endoplasmic reticulum stress involved in oocyte aging: an analysis using single-cell RNA-sequencing of mouse oocytes

• Auteurs principaux: Tao Zhang (Auteur), Qingsong Xi (Auteur), Dan Wang (Auteur), Jingjing Li (Auteur), Meng Wang (Auteur), Dan Li (Auteur), Lixia Zhu (Auteur), Lei Jin (Auteur)
• Format: Livre
• Publié: BMC, 2019-06-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Abstract Object To explore the mechanisms of ovarian aging, we performed overall analysis on the age-related alterations of gene expression profiles in mouse germinal vesicle (GV) stage oocytes by means of single-cell RNA-sequencing method (scRNA-seq). Methods Two age groups (5-week-old and 32-week-...