Dually Active Polycation/miRNA Nanoparticles for the Treatment of Fibrosis in Alcohol-Associated Liver Disease

• Main Authors: Chuhan Zhang (Author), Yu Hang (Author), Weimin Tang (Author), Diptesh Sil (Author), Heather C. Jensen-Smith (Author), Robert G. Bennett (Author), Benita L. McVicker (Author), David Oupický (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alcohol-associated liver disease (AALD) is a major cause of liver disorders worldwide. Current treatment options are limited, especially for AALD-associated fibrosis. Promising approaches include RNA interference for miR-155 overexpression in Kupffer cells (KCs), as well as the use of CXCR4 antagoni...