Dually Active Polycation/miRNA Nanoparticles for the Treatment of Fibrosis in Alcohol-Associated Liver Disease

• Prif Awduron: Chuhan Zhang (Awdur), Yu Hang (Awdur), Weimin Tang (Awdur), Diptesh Sil (Awdur), Heather C. Jensen-Smith (Awdur), Robert G. Bennett (Awdur), Benita L. McVicker (Awdur), David Oupický (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2022-03-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Alcohol-associated liver disease (AALD) is a major cause of liver disorders worldwide. Current treatment options are limited, especially for AALD-associated fibrosis. Promising approaches include RNA interference for miR-155 overexpression in Kupffer cells (KCs), as well as the use of CXCR4 antagoni...