Use of a MAIT Activating Ligand, 5-OP-RU, as a Mucosal Adjuvant in a Murine Model of Vibrio cholerae O1 Vaccination

• Main Authors: Owen Jensen (Author), Shubhanshi Trivedi (Author), Kelin Li (Author), Jeffrey Aubé (Author), J. Scott Hale (Author), Edward T. Ryan (Author), Daniel T Leung (Author)
• Format: Book
• Published: Case Western Reserve University, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Mucosal-associated invariant T (MAIT) cells are innate-like T cells enriched in the mucosa with capacity for B-cell help. We hypothesize that targeting MAIT cells, using a MAIT-activating ligand as an adjuvant, could improve mucosal vaccine responses to bacterial pathogens such as Vibrio...