Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?

• Autori principali: Li-Chun eLin (Autore), Etienne eSibille (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2013-09-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Our knowledge of the pathophysiology of affect dysregulation has progressively increased, but the pharmacological treatments remain inadequate. Here, we summarize the current literature on deficits in somatostatin, an inhibitory modulatory neuropeptide, in major depression and other neurological dis...