Efficacy of single versus four repeated doses of praziquantel against Schistosoma mansoni infection in school-aged children from Côte d'Ivoire based on Kato-Katz and POC-CCA: An open-label, randomised controlled trial (RePST).

• Main Authors: Pytsje T Hoekstra (Author), Miriam Casacuberta-Partal (Author), Lisette van Lieshout (Author), Paul L A M Corstjens (Author), Roula Tsonaka (Author), Rufin K Assaré (Author), Kigbafori D Silué (Author), Aboulaye Meité (Author), Eliézer K N'Goran (Author), Yves K N'Gbesso (Author), Abena S Amoah (Author), Meta Roestenberg (Author), Stefanie Knopp (Author), Jürg Utzinger (Author), Jean T Coulibaly (Author), Govert J van Dam (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Preventive chemotherapy with praziquantel (PZQ) is the cornerstone of schistosomiasis control. However, a single dose of PZQ (40 mg/kg) does not cure all infections. Repeated doses of PZQ at short intervals might increase efficacy in terms of cure rate (CR) and intensity reduction rate (I...