A Radiobrominated Tyrosine Kinase Inhibitor for EGFR with L858R/T790M Mutations in Lung Carcinoma

• Main Authors: Muammar Fawwaz (Author), Kenji Mishiro (Author), Ryuichi Nishii (Author), Akira Makino (Author), Yasushi Kiyono (Author), Kazuhiro Shiba (Author), Seigo Kinuya (Author), Kazuma Ogawa (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Activating double mutations L858R/T790M in the epidermal growth factor receptor (EGFR) region are often observed as the cause of resistance to tyrosine kinase inhibitors (TKIs). Third-generation EGFR-TKIs, such as osimertinib and rociletinib (CO-1686), was developed to target such resistance mutatio...