Design, Synthesis, Biological Evaluation, and Molecular Dynamics Studies of Novel Lapatinib Derivatives

• Main Authors: Ahmed Elkamhawy (Author), Seohyun Son (Author), Hwa Young Lee (Author), Mahmoud H. El-Maghrabey (Author), Mohamed A. El Hamd (Author), Saud O. Alshammari (Author), Abeer A. Abdelhameed (Author), Qamar A. Alshammari (Author), Ahmed Abdeen (Author), Samah F. Ibrahim (Author), Wael A. Mahdi (Author), Sultan Alshehri (Author), Radwan Alnajjar (Author), Won Jun Choi (Author), Ahmed A. Al-Karmalawy (Author), Kyeong Lee (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Co-expression of the epidermal growth factor receptor (EGFR, also known as ErbB1) and human epidermal growth factor receptor 2 (HER2) has been identified as a diagnostic or prognostic sign in various tumors. Despite the fact that lapatinib (EGFR/HER2 dual inhibitor) has shown to be successful, many...