Reproductive history determines Erbb2 locus amplification, WNT signalling and tumour phenotype in a murine breast cancer model

• Main Authors: Liliana D. Ordonez (Author), Lorenzo Melchor (Author), Kirsty R. Greenow (Author), Howard Kendrick (Author), Giusy Tornillo (Author), James Bradford (Author), Peter Giles (Author), Matthew J. Smalley (Author)
• Format: Book
• Published: The Company of Biologists, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Understanding the mechanisms underlying tumour heterogeneity is key to the development of treatments that can target specific tumour subtypes. We have previously targeted CRE recombinase-dependent conditional deletion of the tumour suppressor genes Brca1, Brca2, p53 (also known as Trp53) and/or Pten...