Promoter Targeting shRNA Suppresses HIV-1 Infection In vivo Through Transcriptional Gene Silencing

• Main Authors: Kazuo Suzuki (Author), Shinichiro Hattori (Author), Katherine Marks (Author), Chantelle Ahlenstiel (Author), Yosuke Maeda (Author), Takaomi Ishida (Author), Michelle Millington (Author), Maureen Boyd (Author), Geoff Symonds (Author), David A Cooper (Author), Seiji Okada (Author), Anthony D Kelleher (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite prolonged and intensive application, combined antiretroviral therapy cannot eradicate human immunodeficiency virus (HIV)-1 because it is harbored as a latent infection, surviving for long periods of time. Alternative approaches are required to overcome the limitations of current therapy. We...