Vaccine-linked chemotherapy with a low dose of benznidazole plus a bivalent recombinant protein vaccine prevents the development of cardiac fibrosis caused by Trypanosoma cruzi in chronically-infected BALB/c mice.

• Main Authors: Victor Manuel Dzul-Huchim (Author), Maria Jesus Ramirez-Sierra (Author), Pedro Pablo Martinez-Vega (Author), Miguel Enrique Rosado-Vallado (Author), Victor Ermilo Arana-Argaez (Author), Jaime Ortega-Lopez (Author), Fabian Gusovsky (Author), Eric Dumonteil (Author), Julio Vladimir Cruz-Chan (Author), Peter Hotez (Author), María Elena Bottazzi (Author), Liliana Estefania Villanueva-Lizama (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Chagas disease (CD) is caused by Trypanosoma cruzi and affects 6-7 million people worldwide. Approximately 30% of chronic patients develop chronic chagasic cardiomyopathy (CCC) after decades. Benznidazole (BNZ), one of the first-line chemotherapy used for CD, induces t...