Vaccine-linked chemotherapy with a low dose of benznidazole plus a bivalent recombinant protein vaccine prevents the development of cardiac fibrosis caused by Trypanosoma cruzi in chronically-infected BALB/c mice.

• Autori principali: Victor Manuel Dzul-Huchim (Autore), Maria Jesus Ramirez-Sierra (Autore), Pedro Pablo Martinez-Vega (Autore), Miguel Enrique Rosado-Vallado (Autore), Victor Ermilo Arana-Argaez (Autore), Jaime Ortega-Lopez (Autore), Fabian Gusovsky (Autore), Eric Dumonteil (Autore), Julio Vladimir Cruz-Chan (Autore), Peter Hotez (Autore), María Elena Bottazzi (Autore), Liliana Estefania Villanueva-Lizama (Autore)
• Natura: Libro
• Pubblicazione: Public Library of Science (PLoS), 2022-09-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

<h4>Background</h4>Chagas disease (CD) is caused by Trypanosoma cruzi and affects 6-7 million people worldwide. Approximately 30% of chronic patients develop chronic chagasic cardiomyopathy (CCC) after decades. Benznidazole (BNZ), one of the first-line chemotherapy used for CD, induces t...