Preclinical Absorption, Distribution, Metabolism, and Excretion of an Oral Amide Prodrug of Gemcitabine Designed to Deliver Prolonged Systemic Exposure

• Main Authors: Shannon Dow (Author), Richard Burton (Author), Richard Smith (Author), Jingqi Bao (Author), Enaksha Wickremsinhe (Author), Everett Perkins (Author)
• Format: Book
• Published: MDPI AG, 2013-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gemcitabine is an intravenously administered nucleoside analog chemotherapeutic agent. The ability to deliver this agent as an oral drug would allow greater flexibility of administration and patient convenience; however, attempts have been fraught with high first-pass metabolism and potential intest...