Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists

• Main Authors: Aaron Novikoff (Author), Shannon L. O'Brien (Author), Miriam Bernecker (Author), Gerald Grandl (Author), Maximilian Kleinert (Author), Patrick J. Knerr (Author), Kerstin Stemmer (Author), Martin Klingenspor (Author), Anja Zeigerer (Author), Richard DiMarchi (Author), Matthias H. Tschöp (Author), Brian Finan (Author), Davide Calebiro (Author), Timo D. Müller (Author)
• Format: Book
• Published: Elsevier, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: We assessed the spatiotemporal GLP-1 and GIP receptor signaling, trafficking, and recycling dynamics of GIPR mono-agonists, GLP-1R mono-agonists including semaglutide, and GLP-1/GIP dual-agonists MAR709 and tirzepatide. Methods: Receptor G protein recruitment and internalization/trafficki...