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Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists

Objective: We assessed the spatiotemporal GLP-1 and GIP receptor signaling, trafficking, and recycling dynamics of GIPR mono-agonists, GLP-1R mono-agonists including semaglutide, and GLP-1/GIP dual-agonists MAR709 and tirzepatide. Methods: Receptor G protein recruitment and internalization/trafficki...

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Main Authors: Aaron Novikoff (Author), Shannon L. O'Brien (Author), Miriam Bernecker (Author), Gerald Grandl (Author), Maximilian Kleinert (Author), Patrick J. Knerr (Author), Kerstin Stemmer (Author), Martin Klingenspor (Author), Anja Zeigerer (Author), Richard DiMarchi (Author), Matthias H. Tschöp (Author), Brian Finan (Author), Davide Calebiro (Author), Timo D. Müller (Author)
Format: Book
Published: Elsevier, 2021-07-01T00:00:00Z.
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