Prenatal methotrexate injection increases behaviors possibly associated with depression and/or autism in rat offspring; A new animal model for mental disorder, based on folate metabolism deficit during pregnancy

• প্রধান লেখক: Naoki Amada (লেখক), Yusuke Kakumoto (লেখক), Takashi Futamura (লেখক), Kenji Maeda (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Wiley, 2022-09-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract Background Deficiency of folate, an essential vitamin for DNA synthesis and methylation, is reported as a risk factor for mental disorders. Considering a possibility that folate metabolism deficit during pregnancy may disturb CNS development and increase mental disorders in offspring, we tr...