Formulation development of lipid polymer hybrid nanoparticles of doxorubicin and its in-vitro, in-vivo and computational evaluation

• Main Authors: Muhammad Shafique (Author), Maqsood Ur Rehman (Author), Zul Kamal (Author), Rami M. Alzhrani (Author), Sameer Alshehri (Author), Ali H. Alamri (Author), Mohammed Ali Bakkari (Author), Fahad Y. Sabei (Author), Awaji Y. Safhi (Author), Ahmed M. Mohammed (Author), Mohamed A. El Hamd (Author), Saud Almawash (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of this study was to assess the parameters of doxorubicin (DOX) loaded lipid polymer hybrid nanoparticles (LPHNs) formulation development, and then the bioavailability of DOX were determined in the rabbit model, in order to evaluate the intrinsic outcome of dosage form improvement after...