Cyb5r3 links FoxO1-dependent mitochondrial dysfunction with β-cell failure

• Main Authors: Jason Fan (Author), Wen Du (Author), Ja Young Kim-Muller (Author), Jinsook Son (Author), Taiyi Kuo (Author), Delfina Larrea (Author), Christian Garcia (Author), Takumi Kitamoto (Author), Michael J. Kraakman (Author), Edward Owusu-Ansah (Author), Vincenzo Cirulli (Author), Domenico Accili (Author)
• Format: Book
• Published: Elsevier, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Diabetes is characterized by pancreatic β-cell dedifferentiation. Dedifferentiating β cells inappropriately metabolize lipids over carbohydrates and exhibit impaired mitochondrial oxidative phosphorylation. However, the mechanism linking the β-cell's response to an adverse metabolic...