Cyb5r3 links FoxO1-dependent mitochondrial dysfunction with β-cell failure

• मुख्य लेखकों: Jason Fan (लेखक), Wen Du (लेखक), Ja Young Kim-Muller (लेखक), Jinsook Son (लेखक), Taiyi Kuo (लेखक), Delfina Larrea (लेखक), Christian Garcia (लेखक), Takumi Kitamoto (लेखक), Michael J. Kraakman (लेखक), Edward Owusu-Ansah (लेखक), Vincenzo Cirulli (लेखक), Domenico Accili (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2020-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objective: Diabetes is characterized by pancreatic β-cell dedifferentiation. Dedifferentiating β cells inappropriately metabolize lipids over carbohydrates and exhibit impaired mitochondrial oxidative phosphorylation. However, the mechanism linking the β-cell's response to an adverse metabolic...