Maintenance over Time of the Effect Produced by Esmolol on the Structure and Function of Coronary Arteries in Hypertensive Heart Diseases

• Main Authors: Raquel Martín-Oropesa (Author), Pilar Rodríguez-Rodríguez (Author), Laia Pazó-Sayós (Author), Ana Arnalich-Montiel (Author), Silvia Magdalena Arribas (Author), Maria Carmen González (Author), Begoña Quintana-Villamandos (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously observed that esmolol treatment for 48 h reduced vascular lesions in spontaneously hypertensive rats (SHRs). Therefore, we investigated whether this beneficial effect is persistent after withdrawal. Fourteen-month-old SHRs (SHR-Es) were treated with esmolol (300 μg/kg/min) or a vehicle...