T-cell number and subtype influence the disease course of primary chronic lymphocytic leukaemia xenografts in alymphoid mice

• Main Authors: Ceri E. Oldreive (Author), Anna Skowronska (Author), Nicholas J. Davies (Author), Helen Parry (Author), Angelo Agathanggelou (Author), Sergey Krysov (Author), Graham Packham (Author), Zbigniew Rudzki (Author), Laura Cronin (Author), Katerina Vrzalikova (Author), Paul Murray (Author), Elena Odintsova (Author), Guy Pratt (Author), A. Malcolm R. Taylor (Author), Paul Moss (Author), Tatjana Stankovic (Author)
• Format: Book
• Published: The Company of Biologists, 2015-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic lymphocytic leukaemia (CLL) cells require microenvironmental support for their proliferation. This can be recapitulated in highly immunocompromised hosts in the presence of T cells and other supporting cells. Current primary CLL xenograft models suffer from limited duration of tumour cell en...