Synthesis and structure-activity relationships of 2- and/or 4-halogenated 13β- and 13α-estrone derivatives as enzyme inhibitors of estrogen biosynthesis

• Main Authors: Ildikó Bacsa (Author), Bianka Edina Herman (Author), Rebeka Jójárt (Author), Kevin Stefán Herman (Author), János Wölfling (Author), Gyula Schneider (Author), Mónika Varga (Author), Csaba Tömböly (Author), Tea Lanišnik Rižner (Author), Mihály Szécsi (Author), Erzsébet Mernyák (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ring A halogenated 13α-, 13β-, and 17-deoxy-13α-estrone derivatives were synthesised with N-halosuccinimides as electrophile triggers. Substitutions occurred at positions C-2 and/or C-4. The potential inhibitory action of the halogenated estrones on human aromatase, steroid sulfatase, or 17β-hydroxy...