D- and N-Methyl Amino Acids for Modulating the Therapeutic Properties of Antimicrobial Peptides and Lipopeptides

• Κύριοι συγγραφείς: Maria Veronica Humpola (Συγγραφέας), Roque Spinelli (Συγγραφέας), Melina Erben (Συγγραφέας), Virginia Perdomo (Συγγραφέας), Georgina Guadalupe Tonarelli (Συγγραφέας), Fernando Albericio (Συγγραφέας), Alvaro Sebastian Siano (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2023-04-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Here we designed and synthesized analogs of two antimicrobial peptides, namely C10:0-A2, a lipopeptide, and TA4, a cationic α-helical amphipathic peptide, and used non-proteinogenic amino acids to improve their therapeutic properties. The physicochemical properties of these analogs were analyzed, in...