D- and N-Methyl Amino Acids for Modulating the Therapeutic Properties of Antimicrobial Peptides and Lipopeptides

D- and N-Methyl Amino Acids for Modulating the Therapeutic Properties of Antimicrobial Peptides and Lipopeptides

Here we designed and synthesized analogs of two antimicrobial peptides, namely C10:0-A2, a lipopeptide, and TA4, a cationic α-helical amphipathic peptide, and used non-proteinogenic amino acids to improve their therapeutic properties. The physicochemical properties of these analogs were analyzed, in...

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Main Authors: Maria Veronica Humpola (Author), Roque Spinelli (Author), Melina Erben (Author), Virginia Perdomo (Author), Georgina Guadalupe Tonarelli (Author), Fernando Albericio (Author), Alvaro Sebastian Siano (Author)
Format: Book
Published: MDPI AG, 2023-04-01T00:00:00Z.
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