Electrophysiological and Pharmacological Analyses of Nav1.9 Voltage-Gated Sodium Channel by Establishing a Heterologous Expression System

• Main Authors: Xi Zhou (Author), Zhen Xiao (Author), Yan Xu (Author), Yunxiao Zhang (Author), Dongfang Tang (Author), Xinzhou Wu (Author), Cheng Tang (Author), Minzhi Chen (Author), Xiaoliu Shi (Author), Ping Chen (Author), Songping Liang (Author), Zhonghua Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nav1. 9 voltage-gated sodium channel is preferentially expressed in peripheral nociceptive neurons. Recent progresses have proved its role in pain sensation, but our understanding of Nav1.9, in general, has lagged behind because of limitations in heterologous expression in mammal cells. In this work...