Biopharmaceutical Development of a Bifonazole Multiple Emulsion for Enhanced Epidermal Delivery

• Main Authors: Joaquim Suñer-Carbó (Author), Ana Calpena-Campmany (Author), Lyda Halbaut-Bellowa (Author), Beatriz Clares-Naveros (Author), María José Rodriguez-Lagunas (Author), Elena Barbolini (Author), Joanna Zamarbide-Losada (Author), Antonio Boix-Montañés (Author)
• Format: Book
• Published: MDPI AG, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Efficient topical delivery of imidazolic antifungals faces the challenge of overcoming its limited water solubility and its required long-lasting duration of treatments. In this paper, a hydrophilic multiple emulsion (ME) of Bifonazole (BFZ) is shown to maximize its skin retention, minimize its skin...