Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer

• Main Authors: Wagdy M. Eldehna (Author), Rofaida Salem (Author), Zainab M. Elsayed (Author), Tarfah Al-Warhi (Author), Hamada R. Knany (Author), Rezk R. Ayyad (Author), Thamer Bin Traiki (Author), Maha-Hamadien Abdulla (Author), Rehan Ahmad (Author), Hatem A. Abdel-Aziz (Author), Radwan El-Haggar (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the current work, a new set of carbohydrazide linked benzofuran-isatin conjugates (5a-e and 7a-i) was designed and synthesised. The anticancer activity for compounds (5b-d, 7a, 7b, 7d and 7g) was measured against NCI-55 human cancer cell lines. Compound 5d was the most efficient, and thus subject...