A Mouse Model of Sural Nerve Injury-Induced Neuropathy: Gabapentin Inhibits Pain-Related Behaviors and the Hyperactivity of Wide-Dynamic Range Neurons in the Dorsal Horn

• Main Authors: Yu Omori (Author), Kenta Kagaya (Author), Ryugo Enomoto (Author), Atsushi Sasaki (Author), Tsugunobu Andoh (Author), Hiroshi Nojima (Author), Hiroki Takahata (Author), Yasushi Kuraishi (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study was conducted to make a new mouse model of neuropathic pain due to injury to a branch of the sciatic nerve. One of three branches (sural, tibial, and common peroneal nerves) of the sciatic nerve was tightly ligated, and mechanical and cool stimuli were applied to the medial part (tibial a...