PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations
Programmed death-1 (PD-1) is a cell surface receptor that functions as a T cell checkpoint and plays a central role in regulating T cell exhaustion. Binding of PD-1 to its ligand, programmed death-ligand 1 (PD-L1), activates downstream signaling pathways and inhibits T cell activation. Moreover abno...
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Taylor & Francis Group,
2019-05-01T00:00:00Z.
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