PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations

• Glavni autori: Yongshuai Jiang (Autor), Ming Chen (Autor), Hong Nie (Autor), Yuanyang Yuan (Autor)
• Format: Knjiga
• Izdano: Taylor & Francis Group, 2019-05-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Programmed death-1 (PD-1) is a cell surface receptor that functions as a T cell checkpoint and plays a central role in regulating T cell exhaustion. Binding of PD-1 to its ligand, programmed death-ligand 1 (PD-L1), activates downstream signaling pathways and inhibits T cell activation. Moreover abno...