PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations

• Asıl Yazarlar: Yongshuai Jiang (Yazar), Ming Chen (Yazar), Hong Nie (Yazar), Yuanyang Yuan (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2019-05-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Programmed death-1 (PD-1) is a cell surface receptor that functions as a T cell checkpoint and plays a central role in regulating T cell exhaustion. Binding of PD-1 to its ligand, programmed death-ligand 1 (PD-L1), activates downstream signaling pathways and inhibits T cell activation. Moreover abno...