A novel formulation of ketoconazole entrapped in alginate with anionic polymer beads for solubility enhancement: Preparation and characterization

• Main Authors: Viviane Annisa (Author), Teuku Nanda Saifullah Sulaiman (Author), Akhmad Kharis Nugroho (Author), Agung Endro Nugroho (Author)
• Formato: Livro
• Publicado em: Pensoft Publishers, 2023-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Ketoconazole has low solubility in intestinal pH, whereas drug absorption is largest in the small intestine, which can reduce the bioavailability of the drug. Alginate can be combined with a suitable polymer and cross-linked with divalent ions and another polymer to enhance the solubility of the dru...