A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability

• Main Authors: Chiara Fulci (Author), Dante Rotili (Author), Anastasia De Luca (Author), Lorenzo Stella (Author), Blasco Morozzo della Rocca (Author), Mariantonietta Forgione (Author), Veronica Di Paolo (Author), Antonello Mai (Author), Mattia Falconi (Author), Luigi Quintieri (Author), Anna M. Caccuri (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context: The nitrobezoxadiazole derivative NBDHEX is a potent inhibitor of glutathione transferase P1-1 (GSTP1-1) endowed with outstanding anticancer activity in different tumor models. Objective: To characterize by in vitro biochemical and in silico studies the NBDHEX analogues named MC2752 and MC2...