Novel Ordered Stepped-Wedge Cluster Trial Designs for Detecting Ebola Vaccine Efficacy Using a Spatially Structured Mathematical Model.

• Main Authors: Ibrahim Diakite (Author), Eric Q Mooring (Author), Gustavo E Velásquez (Author), Megan B Murray (Author)
• Formato: Livro
• Publicado em: Public Library of Science (PLoS), 2016-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

BACKGROUND:During the 2014 Ebola virus disease (EVD) outbreak, policy-makers were confronted with difficult decisions on how best to test the efficacy of EVD vaccines. On one hand, many were reluctant to withhold a vaccine that might prevent a fatal disease from study participants randomized to a co...