Cloning, characterization, and inhibition of the novel β-carbonic anhydrase from parasitic blood fluke, Schistosoma mansoni

• Hauptverfasser: Susanna Haapanen (Verfasst von), Andrea Angeli (Verfasst von), Martti Tolvanen (Verfasst von), Reza Zolfaghari Emameh (Verfasst von), Claudiu T. Supuran (Verfasst von), Seppo Parkkila (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Schistosoma mansoni is an intestinal parasite with one β-class carbonic anhydrase, SmaBCA. We report the sequence enhancing, production, catalytic activity, and inhibition results of the recombinant SmaBCA. It showed significant catalytic activity on CO2 hydration in vitro with kcat 1.38 × 105 s−1 a...