Design, synthesis and structure-activity relationship studies of 3-phenylpyrazino[1,2-a]indol-1(2H)-ones as amyloid aggregation and cholinesterase inhibitors with antioxidant activity

• প্রধান লেখক: Sarbjeet Singh Gujral (লেখক), Arash Shakeri (লেখক), Leila Hejazi (লেখক), Praveen P.N. Rao (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2022-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

A group of novel fused tricyclic derivatives based on a pyrazino[1,2-a]indol-1(2H)-one ring scaffold possessing a C3 phenyl substituent were designed, synthesized and evaluated as multi-target-directed-ligands (MTDLs) for Alzheimer's disease (AD). The biochemical assays were carried out to dete...