Design, synthesis and structure-activity relationship studies of 3-phenylpyrazino[1,2-a]indol-1(2H)-ones as amyloid aggregation and cholinesterase inhibitors with antioxidant activity

A group of novel fused tricyclic derivatives based on a pyrazino[1,2-a]indol-1(2H)-one ring scaffold possessing a C3 phenyl substituent were designed, synthesized and evaluated as multi-target-directed-ligands (MTDLs) for Alzheimer's disease (AD). The biochemical assays were carried out to dete...

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Main Authors: Sarbjeet Singh Gujral (Author), Arash Shakeri (Author), Leila Hejazi (Author), Praveen P.N. Rao (Author)
Format: Book
Published: Elsevier, 2022-12-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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