Design, synthesis and structure-activity relationship studies of 3-phenylpyrazino[1,2-a]indol-1(2H)-ones as amyloid aggregation and cholinesterase inhibitors with antioxidant activity
A group of novel fused tricyclic derivatives based on a pyrazino[1,2-a]indol-1(2H)-one ring scaffold possessing a C3 phenyl substituent were designed, synthesized and evaluated as multi-target-directed-ligands (MTDLs) for Alzheimer's disease (AD). The biochemical assays were carried out to dete...
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| Main Authors: | , , , |
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| Format: | Book |
| Published: |
Elsevier,
2022-12-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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