Bioisosteric modification on melatonin: synthesis of new naphthalene derivatives, in vitro antioxidant activity and cytotoxicity studies

• Main Authors: Hanif Shirinzadeh (Author), Mohammed Ghalia (Author), Alev Tascioglu (Author), Ferial Intissar Adjali (Author), Gulsen Gunesacar (Author), Hande Gurer-Orhan (Author), Sibel Suzen (Author)
• Format: Book
• Published: Universidade de São Paulo, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Melatonin (MLT) is a strong free radical scavenger that protects the body from the deleterious effects of excess oxidants. Synthesis of MLT analogue compounds with antioxidant potency has recently attracted the interest of researchers. In general, the strategy consists of modifying the groups in the...