A Clinical Drug Library Screen Identifies Tosufloxacin as Being Highly Active against Staphylococcus aureus Persisters

• Main Authors: Hongxia Niu (Author), Peng Cui (Author), Rebecca Yee (Author), Wanliang Shi (Author), Shuo Zhang (Author), Jie Feng (Author), David Sullivan (Author), Wenhong Zhang (Author), Bingdong Zhu (Author), Ying Zhang (Author)
• Format: Book
• Published: MDPI AG, 2015-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To identify effective compounds that are active against Staphylococcus aureus (S. aureus) persisters, we screened a clinical drug library consisting of 1524 compounds and identified six drug candidates that had anti-persister activity: tosufloxacin, clinafloxacin, sarafloxacin, doxycycline, thiostre...