Novel mechanism of napabucasin, a naturally derived furanonaphthoquinone: apoptosis and autophagy induction in lung cancer cells through direct targeting on Akt/mTOR proteins

• Autores principales: Korrakod Petsri (Autor), Sunisa Thongsom (Autor), Satapat Racha (Autor), Supakarn Chamni (Autor), Saresa Jindapol (Autor), Nantawat Kaekratoke (Autor), Hongbin Zou (Autor), Pithi Chanvorachote (Autor)
• Formato: Libro
• Publicado: BMC, 2022-09-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Abstract Background Akt and mTOR are aberrantly activated in cancers and targeting these proteins are interesting for cancer drug discovery. Napabucasin (NB), a phytochemical compound, has been reported as potential anti-cancer agent, however, Akt and mTOR targeting mechanisms remain unclear.  Metho...