Novel mechanism of napabucasin, a naturally derived furanonaphthoquinone: apoptosis and autophagy induction in lung cancer cells through direct targeting on Akt/mTOR proteins

• Main Authors: Korrakod Petsri (Author), Sunisa Thongsom (Author), Satapat Racha (Author), Supakarn Chamni (Author), Saresa Jindapol (Author), Nantawat Kaekratoke (Author), Hongbin Zou (Author), Pithi Chanvorachote (Author)
• Format: Book
• Published: BMC, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Akt and mTOR are aberrantly activated in cancers and targeting these proteins are interesting for cancer drug discovery. Napabucasin (NB), a phytochemical compound, has been reported as potential anti-cancer agent, however, Akt and mTOR targeting mechanisms remain unclear.  Metho...