Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research

• Main Authors: Bárbara Pinto (Author), Ana C. Henriques (Author), Patrícia M. A. Silva (Author), Hassan Bousbaa (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2020-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Most cancer biologists still rely on conventional two-dimensional (2D) monolayer culture techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority of promising preclinical drugs have no or weak efficacy in real patients with tumors, thereby delaying the discov...