Placental Extract Improves Hippocampal Neuronal Loss and Fear Memory Impairment Resulting From Chronic Restraint Stress in Ovariectomized Mice

• Main Authors: Kazuhiro Takuma (Author), Hiroyuki Mizoguchi (Author), Yoko Funatsu (Author), Yuko Kitahara (Author), Daisuke Ibi (Author), Hiroyuki Kamei (Author), Toshio Matsuda (Author), Koji Koike (Author), Masaki Inoue (Author), Taku Nagai (Author), Kiyofumi Yamada (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have recently found that combination of ovariectomy (OVX) and chronic restraint stress causes cognitive dysfunction and reduces hippocampal CA3 neurons in female rats and mice and that estrogen replacement and chronic treatment with Ginkgo biloba extract EGb 761 suppress the OVX/stress-induced be...