Low-dose of caffeine alleviates high altitude pulmonary edema via regulating mitochondrial quality control process in AT1 cells

• Main Authors: Liuyang Tian (Author), Zhilong Jia (Author), Yan Yan (Author), Qian Jia (Author), Wenjie Shi (Author), Saijia Cui (Author), Huining Chen (Author), Yang Han (Author), Xiaojing Zhao (Author), Kunlun He (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Backgrounds: High-altitude pulmonary edema (HAPE) is a life-threatening disease without effective drugs. Caffeine is a small molecule compound with antioxidant biological activity used to treat respiratory distress syndrome. However, it is unclear whether caffeine plays a role in alleviating HAPE.Me...